Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus.
نویسندگان
چکیده
Production of cephamycin c and clavulanic acid by Streptomyces clavuligerus was investigated using different media in shake flask condition. Highest cell growth (3.8 g/L) was observed in glycerol, sucrose, proline and glutamic acid (GSPG) medium. Although, GSPG medium supported maximum growth, it was least effective for the synthesis of both cephamycin and clavulanic acid. Yield of cephamycin and clavulanic acid was maximum in dextrin and K medium, respectively. High and low level of constituents of dextrin medium, affected production of both cephamycin and clavulanic acid. Biosynthesis of clavulanic acid was associated with production of cephamycin c.
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ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 37 10 شماره
صفحات -
تاریخ انتشار 1999